NON-HUMAN PRIMATES IN THE PKPD EVALUATION OF BIOLOGICS: NEEDS AND OPTIONS TO REDUCE, REFINE, AND REPLACE. A BIOSAFE WHITE PAPER

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

Monoclonal antibodies (mAbs) deliver great benefits to patients with chronic and/or severe diseases thanks to their strong specificity to the therapeutic target.As a result of this specificity, non-human primates (NHP) are often the only preclinical species in which therapeutic antibodies cross-react with the target.Here, we highlight the value and

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Negotiating Participant Status in Participation Frameworks

It is not always easy to find your place within a conversation.In this brief piece, I suggest that participant status (i.e., speaker and hearer roles) within a participation framework, is not always Acoustic Preamp agreed upon by all members, but can be asserted, resisted, and otherwise negotiated.In an effort to address this, I will present an exc

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Larvicidal activities of hydro-ethanolic extracts of three Cameroonian medicinal plants against Aedes albopictus

Objective: To investigate the larvicidal activity of Syzygium guineense (Myrtaceae) (S.guineense), Monodora myristica and Zanthoxylum heitzii (Rutaceae) (Z.heitzii) extracts against Aedes albopictus (Ae.albopictus).Methods: The larvicidal activity of the hydro-ethanolic extracts from these plant species was assessed at three different concentration

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Comparison of the clinical characteristics and outcomes of pediatric patients with and without diabetic ketoacidosis at the time of type 1 diabetes diagnosis

Purpose We investigated the possible effects of diabetic ketoacidosis (DKA) at the initial diagnosis of type 1 diabetes mellitus (T1DM) on the clinical outcomes of pediatric patients.Methods Medical records of children and adolescents with newly diagnosed T1DM seen in the Ajou University Hospital from January 2008 to August 2020 Blenders were revie

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